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William E. Miller
William E. 
Miller
, Ph.D.
Assistant Professor

B.S.,Biology-Genetics , Pennsylvania State University , University Park , PA

Ph. D., Microbiology , University of North Carolina , Chapel Hill , NC

Postdoctoral fellow, Howard Hughes Medical Institute , Duke University Medical Center , Durham , NC

Regulation of signal transduction pathways mediated by G-protein coupled receptors (GPCRs) and subversion of these signaling pathways by human pathogens including cytomegalovirus and Bordetella pertussis.

Selected Publications:
  • Schneider, O.D., Weiss, A.A., and Miller, W.E. (2009) Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4. J Immunol, May, 182(9): 5730-9.
  • Sherrill, J. and Miller, W.E. (2008) Invited Review Desensitization of herpesvirus-encoded G protein coupled receptors Life Sciences, January, 82(3-4): 125-34.
  • Stropes, M. and Miller, W.E. (2008) Functional analyses of human cytomegalovirus US28 mutants in infected cells Journal of General Virology, in press
  • Schneider, O. and Miller, W.E. (2007) Pertussis Toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T-cells Infection and Immunity, 75:4040-4049
  • Sherrill, J. and Miller, W.E. (2006) G protein-coupled receptor (GPCR) kinase 2 regulates constitutive Gq/11 signaling from the mouse cytomegalovirus GPCR M33. Journal of Biological Chemistry, 52:39796-39805
  • Wu, J-H., Goswani, R., Kim, L.K., Miller, W.E., Peppel, K. and Freedman, N.J (2005) The PDFR-beta phosphorylates and activates GRK2: A mechanism for feedback inhibition. ournal of Biological Chemistry, 280:31027-31035.
  • Ardilla-Osorio, H., Pioche-Durieu, C., Puvion-Dutilleu, F., Clausse, B, Wiels, J., Miller, W.E., Raab-Traub, N., and Busson, P. (2004) TRAF interactions with raft-like buoyant complexes, better than TRAF rates of degradation, differentiate signaling by CD40 and Epstein-Barr virus latent membrane protein 1 International Journal of Cancer, 113:267-275
  • Witherow, D.S., Garrison, T. R., Miller, W.E., and Lefkowitz, R.J. (2004) Beta-arrestin2 inhibits NF-kB activity by means of its interaction with the NF-kB inhibitor IkBa Proc Natl. Acad. Sci., 101:8603-8607
  • Stropes, M. and Miller, W.E. (2004) ignaling and regulation of G-protein coupled receptors encoded by cytomegaloviruses. Biochemistry and Cell Biology, 82:636-642.
  • Mialet-Perez, J., Green, S.A., Miller, W.E. and Liggett, S.B. (2004) A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation. Journal of Biological Chemistry, 279:38603-38607.
  • Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L.A., Miller, W.E., Caron, M.G., Barak, L.S., Nusse, R. and Lefkowitz, R.J. (2003) Dishevelled 2 recruits beta-arrestin2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science, 301:1391-1394.
  • Miller, W.E., Houtz, D.A., Nelson, C.D., Kolattukudy, P.E. and Lefkowitz, R.J. (2003) GRK phosphorylation and beta-arrestin binding regulate the constitutive signaling activity of the Human Cytomegalovirus US28 GPCR. Journal of Biological Chemistry, 278:21663-21671.

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