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Edmund Choi
Edmund 
Choi
, Ph.D.
Associate Professor

A.B. Bacteriology, 1975 , University Of Berkeley , Berkeley , CA

Ph.D. Microbiology and Immunology 1981 , University of California , Los Angeles , CA

The interactions between T cell receptors (TCR) and MHC molecules are critical for antigen-recognition in the immune response. Current studies include an analysis of TCR Vb genetic polymorphisms and their associations with specific disease subtypes in patients with juvenile rheumatoid arthritis (JRA). This is combined with the identification of clonally expanded TCRs found in the synovial samples from JRA patients. The characterization of these T cells will increase our understanding of the immunologic mechanisms responsible for this autoimmune disease.

Selected Publications:
  • Brzezinski, J.L., Deka, R., Menon, A.G., Glass, D.N. and Choi, E. (2005) Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations. Int. J. Immunogenet. 32(6):413-20.
  • Brzezinski, JL, Glass, DN, and Choi E. (2001) A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes. Genes Immun. 2(5):290-1.
  • Thompson, S.D., Murray, K.J., Grom, A.A., Passo, M.H. Choi, E., and Glass, D.N. (1998) Comparative sequence analysis of the human T cell receptor b chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies. Arthritis and Rheumatism 41:482-497.
  • Grom, A.A., von Knorre, C., Murray, K.J., Donnelly, P.A., Glass, D.N. and Choi, E. (1996) T-cell receptor BV6S1 null alleles and HLA-DR1 haplotypes in polyarticular outcome juvenile rheumatoid arthritis. Hum. Immunol. 45:152-156
  • Cullen, C.M., Blanco, L.R., Bonventre, P.F., Choi, E. (1995) A toxic shock syndrome toxin-1 mutant that defines a functional site critical for T cell activation. Infect. & Immun. 63:2141-2146.
  • Luyrink L., Gabriel, C.A. Thompson, S.D., Grom, A.A. Maksymowych, W.P., Choi, E., and Glass, D.N. (1993) Reduced expression of a Vb6.1 T cell receptor gene. Proc. Natl. Acad. Sci. USA 90:4369-4373.

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