Genetics of heavy metal tolerance/sensitivity in eukaryotes; epigenetic effects of environmental toxins and carcinogens.

Molecular immunology; T cell receptor and MHC class II genes in human autoimmune disease.

Molecular neuroendocrinology; chromaffin granule structure, function, and biogenesis; Alzheimer's disease paired helical filament (PHF) protein identity and cDNA cloning; fungal physiology

is an expert in host response to the pathogenic fungi, Histoplasma capsulatum, and is well versed in the evolution of the T cell response to this pathogen.

has initiated genomic and proteomic analyses of Burkholderia pseudomallei and Francisella tularensis.

Biophysical & crystallographic studies of cellular adhesion & receptor signaling

Protein-crystallography and biochemical methods to address structure-function questions that underlie the molecular mechanisms of Notch signaling.

Gene regulation and developmental biology, vascular and endothelial biology, atherosclerosis, and the role of the Na,K-ATPase in hypertension

Ion channels in cardiovascular disease

Regulation of signal transduction pathways mediated by G-protein coupled receptors (GPCRs) and subversion of these signaling pathways by human pathogens including cytomegalovirus and Bordetella pertussis.

Transcriptional control of cardiac development and hypertrophy

Immunogenetics; molecular genetics of the major histocompatibility complex; antigen processing; proteasomes and protein degradation

Development and application of solution-state NMR spectroscopy in studies of macromolecular structure and dynamics

Is examining the structure/function relationships of the Bordetella pertussis adenylate cyclase toxin, anthrax edema factor toxin and Shiga toxin.

Dr. Rothenberg's research is focused on how the immune system normally responds to toxic agents including allergens. His interest in bioterrorism also relates to adverse vaccination events including eczema vaccinatum and atopic dermatitis, associated with smallpox vaccination.

Role of ion-transport proteins in cardiac, renal, and gastrointestinal function using gene targeting technology

Has developed novel mouse models to study genetic instability in the various cell-types in the body. This work pertains to cancer and aging. The Stringer group also studies Pneumocystis carinii, a pathogenic fungus that poses a major threat to the health of immunocompromised patients.

Is investigating vaccines and novel therapeutic approaches to counter anthrax toxin and Shiga toxin. She also studies Shiga toxin production by E. coli O157:H7 and pertussis toxin.

Cardiac and skeletal muscle protein expression and disease using transgenic mouse models and bioinformatics.