Departmental Faculty

Genetics of heavy metal tolerance/sensitivity in eukaryotes; epigenetic effects of environmental toxins and carcinogens.

Molecular immunology; T cell receptor and MHC class II genes in human autoimmune disease.

Molecular neuroendocrinology; chromaffin granule structure, function, and biogenesis; Alzheimer's disease paired helical filament (PHF) protein identity and cDNA cloning; fungal physiology

is an expert in host response to the pathogenic fungi, Histoplasma capsulatum, and is well versed in the evolution of the T cell response to this pathogen.

Cellular basis of learning and memory; How neuronal networks decode calcium oscillations.

has initiated genomic and proteomic analyses of Burkholderia pseudomallei and Francisella tularensis.

Biophysical & crystallographic studies of cellular adhesion & receptor signaling

Protein-crystallography and biochemical methods to address structure-function questions that underlie the molecular mechanisms of Notch signaling.

Role of growth factors in development, particularly megakaryopoiesis

Gene regulation and developmental biology, vascular and endothelial biology, atherosclerosis, and the role of the Na,K-ATPase in hypertension

Ion channels in cardiovascular disease

Regulation of signal transduction pathways mediated by G-protein coupled receptors (GPCRs) and subversion of these signaling pathways by human pathogens including cytomegalovirus and Bordetella pertussis.

Immunogenetics; molecular genetics of the major histocompatibility complex; antigen processing; proteasomes and protein degradation

Telomere structure and function including mechanisms of telomere replication, role of telomere proteins in telomere length regulation, telomere signaling and telomere end-protection

Development and application of solution-state NMR spectroscopy in studies of macromolecular structure and dynamics

Is examining the structure/function relationships of the Bordetella pertussis adenylate cyclase toxin, anthrax edema factor toxin and Shiga toxin.

Bacterial toxins: intracellular trafficking in mammalian cells; toxin-induced apoptosis in tissue culture and in an experimental mouse model

Role of ion-transport proteins in cardiac, renal, and gastrointestinal function using gene targeting technology

Genome analysis; Epistasis and evolution in complex systems; Technology and business innovation

Has developed novel mouse models to study genetic instability in the various cell-types in the body. This work pertains to cancer and aging. The Stringer group also studies Pneumocystis carinii, a pathogenic fungus that poses a major threat to the health of immunocompromised patients.

Is investigating vaccines and novel therapeutic approaches to counter anthrax toxin and Shiga toxin. She also studies Shiga toxin production by E. coli O157:H7 and pertussis toxin.

Cardiac and skeletal muscle protein expression and disease using transgenic mouse models and bioinformatics.